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Many people on the lowest calorie intake in trying to slim down find considerable often ill tempered etc anxious. Reductions in serotonin may be partially responsible here. One recent study (The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under panic. Am J Clin Nutr 2000 Jun;71(6):1536-1544) examined whether alpha-lactalbumin - a serious sub fraction found in whey which has an especially high tryptophan content - would increase plasma Tryptophan levels too reduce depression and cortisol concentrations in subjects under acute stress considered to be vulnerable to worry.
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PGF 2 derivatives are used to medically lower IOP by affecting the FP receptor. These include latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) works on the complementary IOP-lowering but anti-inflammatory PGE 2 pathway through c-AMP-mediated EP 2, EP 3 and EP 4 receptors.
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